On Acquisition and Analysis of a Dataset Comprising of Gait, Ear and Semantic data

In outdoor scenarios such as surveillance where there is very little control over the environments, complex computer vision algorithms are often required for analysis. However constrained environments, such as walkways in airports where the surroundings and the path taken by individuals can be controlled, provide an ideal application for such systems. Figure 1.1 depicts an idealised constrained environment. The path taken by the subject is restricted to a narrow path and once inside is in a volume where lighting and other conditions are controlled to facilitate biometric analysis. The ability to control the surroundings and the flow of people greatly simplifes the computer vision task, compared to typical unconstrained environments. Even though biometric datasets with greater than one hundred people are increasingly common, there is still very little known about the inter and intra-subject variation in many biometrics. This information is essential to estimate the recognition capability and limits of automatic recognition systems. In order to accurately estimate the inter- and the intra- class variance, substantially larger datasets are required [40]. Covariates such as facial expression, headwear, footwear type, surface type and carried items are attracting increasing attention; although considering the potentially large impact on an individuals biometrics, large trials need to be conducted to establish how much variance results. This chapter is the first description of the multibiometric data acquired using the University of Southampton's Multi-Biometric Tunnel [26, 37]; a biometric portal using automatic gait, face and ear recognition for identification purposes. The tunnel provides a constrained environment and is ideal for use in high throughput security scenarios and for the collection of large datasets. We describe the current state of data acquisition of face, gait, ear, and semantic data and present early results showing the quality and range of data that has been collected. The main novelties of this dataset in comparison with other multi-biometric datasets are: 1. gait data exists for multiple views and is synchronised, allowing 3D reconstruction and analysis; 2. the face data is a sequence of images allowing for face recognition in video; 3. the ear data is acquired in a relatively unconstrained environment, as a subject walks past; and 4. the semantic data is considerably more extensive than has been available previously. We shall aim to show the advantages of this new data in biometric analysis, though the scope for such analysis is considerably greater than time and space allows for here

Markerless View Independent Gait Analysis with Self-camera Calibration

We present a new method for viewpoint independent markerless gait analysis. The system uses a single camera, does not require camera calibration and works with a wide range of directions of walking. These properties make the proposed method particularly suitable for identification by gait, where the advantages of completely unobtrusiveness, remoteness and covertness of the biometric system preclude the availability of camera information and use of marker based technology. Tests on more than 200 video sequences with subjects walking freely along different walking directions have been performed. The obtained results show that markerless gait analysis can be achieved without any knowledge of internal or external camera parameters and that the obtained data that can be used for gait biometrics purposes. The performance of the proposed method is particularly encouraging for its appliance in surveillance scenarios

Evolution of the mineralogy, pore structure and transport properties of Nordland Shale following exposure to supercritical carbon dioxide

The Nordland shale forms the caprock of the Utsira sands of the Sleipner reservoir currently used for carbon dioxide sequestration. The long-term exposure of shale rocks to supercritical carbon dioxide (scCO2), or scCO2-brine mixtures, may lead to structural and chemical changes in shale that lead to increases in permeability of inter-layers and caprocks, that may mean changes to plume migration behaviour and/or loss of seal efficiency of caprocks. A detailed study has been made of the initial pore structure of Nordland shale and the changes following accelerated treatment with scCO2. Gas sorption scanning curves have suggested that the void space of the original shale consisted of a Network (denoted 1) of micropores and smaller mesopores that is thermodynamically independent of a Network (2) of larger mesopores and macropores. This work introduces a new iodononane pre-adsorption technique to map the macroscopic (>microns) spatial distribution of micropores (<2 nm) and smaller mesopores in shales using CXT. CXT imaging of shale samples with iodononane pre-adsorbed in Network 1, or with entrapped mercury confined to only Network 2, suggested that both small- and large-sized pore networks were pervasive through the shale and associated with the continuous illite matrix phase. The feldspar and quartz grains did not form part of either network, though inter-particle macropores were found surrounding these mineral grains from CXT imaging of mercury entrapped there. Kinetic gas uptake experiments conducted on samples before and after filling Network 1 with iodononane suggested that the smaller mesopores were, despite their small size and thermodynamic independence from the macropores, still critical to mass transport, with the diffusion flux being funnelled through them. Shale surface areas obtained using the homotattic patch adsorption model were found more physically realistic than those determined via the ISO BET method since multi-linear regression of only the logarithm of the former, together with that of the Network 1 pore volume, predicted the gas-phase mass transport coefficient following treatment. This work demonstrated the need for the novel characterisation methods and data analysis presented here to properly understand the structure-transport relationship in shales exposed to scCO2

Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface

Plasma concentrations of biologically active vitamin D (1,25- (OH)2D) are tightly controlled via feedback regulation of renal 1-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes. In pregnancy, this regulation is uncoupled, and 1,25-(OH)2D levels are significantly elevated, suggesting a role in pregnancy progression. Epigenetic regulation of CYP27B1 and CYP24A1 has previously been described in cell and animal models, and despite emerging evidence for a critical role of epigenetics in placentation generally, little is known about the regulation of enzymes modulating vitamin D homeostasis at the fetomaternal interface. In this study, we investigated the methylation status of genes regulating vitamin D bioavailability and activity in the placenta. No methylation of the VDR (vitamin D receptor) and CYP27B1 genes was found in any placental tissues. In contrast, the CYP24A1 gene is methylated in human placenta, purified cytotrophoblasts, and primary and cultured chorionic villus sampling tissue. No methylation was detected in any somatic human tissue tested. Methylation was also evident in marmoset and mouse placental tissue. All three genes were hypermethylated in choriocarcinoma cell lines, highlighting the role of vitaminDderegulation in this cancer. Gene expression analysis confirmed a reduced capacity for CYP24A1 induction with promoter methylation in primary cells and in vitro reporter analysis demonstrated that promoter methylation directly down-regulates basal promoter activity and abolishes vitamin D-mediated feedback activation. This study strongly suggests that epigenetic decoupling of vitamin D feedback catabolism plays an important role in maximizing active vitamin D bioavailability at the fetomaternal interface

Effect of selenium supplementation on CD4 T-cell recovery, viral suppression, morbidity and quality of life of HIV-infected patients in Rwanda: study protocol for a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>Low levels of serum selenium are associated with increased risk of mortality among HIV+ patients in East Africa. We aim to assess the effect of selenium supplementation on CD4 cell count, HIV viral load, opportunistic infections, and quality of life in HIV-infected patients in Rwanda.</p> <p>Methods and Design</p> <p>A 24-month, multi-centre, patient and provider-blinded, randomized, placebo-controlled clinical trial involving 300 pre-antiretroviral therapy (ART) HIV-infected patients will be carried out at two sites in Rwanda. Patients ≥ 21 years of age with documented HIV infection, CD4 cell count of 400-650 cells/mm³, and not yet on ART will be recruited. Patients will be randomized at each study site using a randomized block design to receive either the selenium micronutrient supplement or an identically appearing placebo taken once daily. The primary outcome is a composite of time from baseline to reduction of CD4 T lymphocyte count below 350 cells/mm³ (confirmed by two measures at least one week apart), or start of ART, or the emergence of a documented CDC-defined AIDS-defining illness. An intention-to-treat analysis will be conducted using stepwise regression and structural equation modeling.</p> <p>Discussion</p> <p>Micronutrient interventions that aim to improve CD4 cell count, decrease opportunistic infections, decrease HIV viral load, and ultimately delay initiation of more costly ART may be beneficial, particularly in resource-constrained settings, such as sub-Saharan Africa. Additional trials are needed to determine if micro-supplementation can delay the need for more costly ART among HIV-infected patients. If shown to be effective, selenium supplementation may be of public health importance to HIV-infected populations, particularly in sub-Saharan Africa and other resource-constrained settings.</p> <p>Trial Registration</p> <p><a href="http://www.clinicaltrials.gov/ct2/show/NCT01327755">NCT01327755</a></p

Towards an Intelligent Tutor for Mathematical Proofs

Computer-supported learning is an increasingly important form of study since it allows for independent learning and individualized instruction. In this paper, we discuss a novel approach to developing an intelligent tutoring system for teaching textbook-style mathematical proofs. We characterize the particularities of the domain and discuss common ITS design models. Our approach is motivated by phenomena found in a corpus of tutorial dialogs that were collected in a Wizard-of-Oz experiment. We show how an intelligent tutor for textbook-style mathematical proofs can be built on top of an adapted assertion-level proof assistant by reusing representations and proof search strategies originally developed for automated and interactive theorem proving. The resulting prototype was successfully evaluated on a corpus of tutorial dialogs and yields good results.Comment: In Proceedings THedu'11, arXiv:1202.453

Expressions 1978

Expressions contains selected work from some of the Creative Writing Contest winners and honorable mentions along with Commercial Art students at Des Moines Area Community College. Design, topography, and layout was accomplished by Journalism students.https://openspace.dmacc.edu/expressions/1000/thumbnail.jp

Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative

Patients with rare and complex diseases such as congenital adrenal hyperplasia (CAH) often receive fragmented and inadequate care unless efforts are coordinated among providers. Translating the concepts of the medical home and comprehensive health care for individuals with CAH offers many benefits for the affected individuals and their families. This manuscript represents the recommendations of a 1.5 day meeting held in September 2009 to discuss the ideal goals for comprehensive care centers for newborns, infants, children, adolescents, and adults with CAH. Participants included pediatric endocrinologists, internal medicine and reproductive endocrinologists, pediatric urologists, pediatric surgeons, psychologists, and pediatric endocrine nurse educators. One unique aspect of this meeting was the active participation of individuals personally affected by CAH as patients or parents of patients. Representatives of Health Research and Services Administration (HRSA), New York-Mid-Atlantic Consortium for Genetics and Newborn Screening Services (NYMAC), and National Newborn Screening and Genetics Resource Center (NNSGRC) also participated. Thus, this document should serve as a “roadmap” for the development phases of comprehensive care centers (CCC) for individuals and families affected by CAH

Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative

Patients with rare and complex diseases such as congenital adrenal hyperplasia (CAH) often receive fragmented and inadequate care unless efforts are coordinated among providers. Translating the concepts of the medical home and comprehensive health care for individuals with CAH offers many benefits for the affected individuals and their families. This manuscript represents the recommendations of a 1.5 day meeting held in September 2009 to discuss the ideal goals for comprehensive care centers for newborns, infants, children, adolescents, and adults with CAH. Participants included pediatric endocrinologists, internal medicine and reproductive endocrinologists, pediatric urologists, pediatric surgeons, psychologists, and pediatric endocrine nurse educators. One unique aspect of this meeting was the active participation of individuals personally affected by CAH as patients or parents of patients. Representatives of Health Research and Services Administration (HRSA), New York-Mid-Atlantic Consortium for Genetics and Newborn Screening Services (NYMAC), and National Newborn Screening and Genetics Resource Center (NNSGRC) also participated. Thus, this document should serve as a “roadmap” for the development phases of comprehensive care centers (CCC) for individuals and families affected by CAH